Hello guys, Welcome to Africa's Largest Video Search Engine, and you are watching Bruce Patterson - Bioinformatics and Quantitative Genomics in Cervical Cancer Screening. and this video is uploaded by Labroots at 2013-09-10T14:32:46-07:00. We are just promoting this video only for entertainment and educational purpose only. I hop you like our Video Search Engine. [JBdiUu32zCE]
| Name | Bruce Patterson - Bioinformatics and Quantitative Genomics in Cervical Cancer Screening |
| Video Uploader | Video From Labroots |
| Upload Date | This Video Uploaded At 10-09-2013 21:32:46 |
| Video Discription | Watch on LabRoots at: http://labroots.com/user/webinars/details/id/45 Cervical cancer screening has evolved significantly since the PAP smear was introduced in 1949. In particular, the association with human papillomavirus (HPV) infection and the mechanism of HPV-related carcinogenesis have been elucidated over the last 20 years. Diagnostics quickly followed focusing on the presence or absence of HPV. Because HPV is ubiquitous and the presence of a high risk type of HPV results in high grade cervical lesions in a small number of instances, the field has realized that infection by HPV is not enough to appropriately triage affected individuals into treatment categories. Detection of HPV DNA has high sensitivity (95 percent+) for high grade cervical lesions but low specificity (less than 40 percent). The Pap smear has higher specificity for high grade lesions but low sensitivity. Further, the combination of a slide-based morphologic examination and a highly automated molecular determination of HPV infection is a work-flow challenge for clinical diagnostics. Further, new biomarkers including quantification of HPV oncogenes E6 and E7 as well as cell cycle related proteins associated with inactivation of the rb and p53 tumor suppressor genes offer more promising approaches for cervical cancer screening. In addition, bioinformatics approaches can combine multiple biomarkers (including morphometric biomarkers) to provide algorithms more predictive of precervical cancer and cervical cancer than the presence or absence of HPV DNA. [JBdiUu32zCE] |
| Category | People & Blogs |
| Tags | People & Blogs Download MP4 | People & Blogs Download MP3 | People & Blogs Download MP4 360p | People & Blogs Download MP4 480p | People & Blogs Download MP4 720p | People & Blogs Download MP4 1080p |
