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| Name | In vitro study of silanol on skin fibroblasts - Video abstract [ID 167078] |
| Video Uploader | Video From Dove Medical Press |
| Upload Date | This Video Uploaded At 06-09-2018 22:15:39 |
| Video Discription | Video abstract of an original research "In vitro study of RRS® Silisorg CE Class III medical device composed of silanol: effect on human skin fibroblasts and its clinical use" published in the open access journal Medical Devices: Evidence and Research by Deglesne, Arroyo, Lopez et al. Introduction: Silanol (organic silicon) has been used for decades in the treatment of skin photoaging as it stabilizes and maintains skin structures through hydrogen bonding electrostatic interaction with extracellular matrix (ECM) proteins or glycosaminoglycans. Organic siliconbased products are often presented as silanol derivatives which are currently associated to other structural molecules such as orthohydroxybenzoate, carboxymethyl theophylline alginate, ascorbate, acetyltyrosine, sodium lactate or mannuronate. Consequently, organic silicon formulations may differ substantially between the medical devices available on the market, which may result in additional effect on the skin. Therefore, there is a real need for a better characterization of the products in terms of their action on human skin and in vitro skin model. Materials and methods: In this in vitro study, the effect of RRSR Silisorg was analyzed. RRSR Silisorg is a dermal implant (CE Class III medical device) containing monomethylsilanol mannuronate associated to an antioxidant resveratrol. Skin fibroblast viability and capacity to induce the production of key ECM genes were evaluated in the presence of different concentrations of RRSR Silisorg. The key ECM genes selected were collagen type I, elastin and hyaluronan synthase type 2 (HAS2), which is the cellular enzyme responsible for high molecular weight hyaluronic acid (HA) production. Viability was evaluated through 3-(4,5-dimethylthiazol-2 yl)-2,5-diphenyltetrazolium bromide) assay and expression was quantified by quantitative polymerase chain reaction. Results: RRSR Silisorg increased fibroblast gene expression of HAS2 in the first 24 hours, 25 times in the presence of 1 mg/mL of solution, followed by a collagen type I gene expression (4.7 times) and elastin expression (2.5 times) increase after 48 hours. Conclusion: These results demonstrate that the silanol-based medical device RRSR Silisorg sustains HA, collagen and elastin production in human skin fibroblasts in vitro. Read the original research paper here: https://www.dovepress.com/in-vitro-study-of-rrsreg-silisorg-ce-class-iii-medical-device-composed-peer-reviewed-article-MDER [8s6ZDbhPWi0] |
| Category | Science & Technology |
| Tags | Dove Medical Press | dovepress | Deglesne | Skin Tech Pharma Group | dermal implant | mesotherapy | hyaluronic acid | collagen | organic silicon | photoaging |
