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| Name | Evolutionary change in hippocampus and brain structure shown from human back to mouse. |
| Video Uploader | Video From USC Stevens Neuroimaging and Informatics Institute |
| Upload Date | This Video Uploaded At 03-05-2021 21:25:40 |
| Video Discription | This video shows the evolutionary change in hippocampus and brain structure shown from human back to mouse. The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across species makes it unclear how the laminar organization is represented in human subiculum. Using in situ hybridization data from the Allen Human Brain Atlas, we demonstrate that the human subiculum also contains complementary laminar gene expression patterns similar to the mouse. In addition, we provide evidence that the molecular domain boundaries in human subiculum correspond to microstructural differences observed in high resolution MRI and fiber density imaging. Finally, we show both similarities and differences in the gene expression profile of subiculum pyramidal cells within homologous lamina. Overall, we present a new 3D model of the anatomical organization of human subiculum and its evolution from the mouse. Michael S. Bienkowski, Farshid Sepehrband, Nyoman D. Kurniawan, Jim Stanis, Laura Korobkova, Neda Khanjani, Kristi Clark, Houri Hintiryan, Carol A. Miller & Hong-Wei Dong [sWiYJ9dERgA] |
| Category | Science & Technology |
| Tags | Science & Technology Download MP4 | Science & Technology Download MP3 | Science & Technology Download MP4 360p | Science & Technology Download MP4 480p | Science & Technology Download MP4 720p | Science & Technology Download MP4 1080p |
