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சர்க்கரை நோய்க்கு நிரந்தர தீர்வு |China Found Medicine for Diabetes|Good news for Diabetic Patients
Chinese scientists develop cure for diabetes, insulin patient becomes medicine-free in just 3 months
Synopsis
Chinese scientists achieve diabetes cure through innovative cell therapy, detailed in Cell Discovery. Patient, treated in July 2021, no longer requires insulin after eleven weeks, and is now medication-free for 33 months. The breakthrough, praised by Timothy Kieffer, signifies a major advancement in diabetes treatment. This novel approach utilizes the body's regenerative abilities and could alleviate China's care burden. Further studies are needed for validation.
A 59-year-old man with type 2 diabetes who needed multiple insulin injections daily was given an innovative cell transplant
He has now been insulin-free for 33 months and is not on any other medication, giving hope to other diabetes sufferers
For patients battling diabetes, a group of Chinese scientists and clinicians may offer a glimmer of hope. For the first time in the world, a patient’s diabetes has reportedly been cured using cell therapy.
The patient, a 59-year-old man who had been living with type 2 diabetes for 25 years, was at serious risk of complications from the disease. He had a kidney transplant in 2017, but had lost most of his pancreatic islet function which controls blood glucose levels, and relied on multiple insulin injections every day.
“He was at great risk of serious diabetes complications,” Yin Hao, a leading researcher at Shanghai Changzheng Hospital, told Shanghai-based news outlet The Paper earlier this month.
The patient received the innovative cell transplant in July 2021. Eleven weeks after the transplant, he was free of the need for external insulin, and the dose of oral medication to control blood sugar levels was gradually reduced and completely stopped one year later.
“Follow-up examinations showed that the patient’s pancreatic islet function was effectively restored,” Yin said. The patient has now been completely weaned off insulin for 33 months.
The medical breakthrough, achieved by a team of doctors and researchers from institutions including Shanghai Changzheng Hospital, the Centre for Excellence in Molecular Cell Science under the Chinese Academy of Sciences, and Renji Hospital, all based in Shanghai, was published in the journal Cell Discovery on April 30.
“I think this study represents an important advance in the field of cell therapy for diabetes,” said Timothy Kieffer, a professor in the department of cellular and physiological sciences at the University of British Columbia in Canada.
What we consume is broken down into glucose – a simple sugar – and released into the bloodstream. Insulin, produced by the islets of the pancreas, is essential for regulating blood sugar levels.
In diabetes, this system is hijacked: either the body does not produce enough insulin, or it cannot use the insulin it produces effectively.
There are several types of diabetes, of which type 2 is the most common, affecting almost 90 per cent of sufferers. It is largely diet-related and develops over time.
Regardless of the type of diabetes, failure to maintain normal blood glucose levels over time can lead to serious side effects, including heart disease, vision loss and kidney disease.
According to the US Centres for Disease Control and Prevention, “there isn’t a cure yet for diabetes”.
Along with losing weight, eating well and taking medication, insulin is the mainstay of treatment for some, but this requires frequent injections and monitoring.
Scientists around the world are researching islet transplant as a promising alternative, mainly by creating islet-like cells from human stem cell cultures. Now, after more than a decade of work, the group of Chinese scientists has come a step closer.
The team used and programmed the patient’s own peripheral blood mononuclear cells, Yin said, which were then transformed into “seed cells” and reconstituted pancreatic islet tissue in an artificial environment.
China’s diabetic population is disproportionately high, according to Huang Yanzhong, a senior fellow for global health at the Council on Foreign Relations. But to get there, he added, studies in more patients based on the findings of this Chinese study were needed.
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