Hello guys, Welcome to Africa's Largest Video Search Engine, and you are watching Powering Neurons with Light | Optogenetics and the Maestro multielectrode array (MEA) system. and this video is uploaded by Axion BioSystems at 2021-02-08T05:50:00-08:00. We are just promoting this video only for entertainment and educational purpose only. I hop you like our Video Search Engine. [koTQG-LJ6gg]
| Name | Powering Neurons with Light | Optogenetics and the Maestro multielectrode array (MEA) system |
| Video Uploader | Video From Axion BioSystems |
| Upload Date | This Video Uploaded At 08-02-2021 13:50:00 |
| Video Discription | Using the Lumos optical stimulator and Axion's multiwell Maestro MEA system to study neural network activity with optogenetics. Learn more: https://www.axionbiosystems.com/applications/neural-activity/neural-optical-and-electrical-stimulation Neurons on the left side of the dish have been transduced with a blue light-activated ion channel (channel rhodopsin, ChR2), the neurons on the right have not. Watch as blue light induces activity in the ChR2-labeled left-side neural population, that then spreads to, and activates the unlabeled right-side neural population. What is a multiwell MEA assay? Axion’s microelectrode array (MEA), also known as multielectrode array, plates have a grid of tightly spaced electrodes embedded in the culture surface of each well. Electrically active cells, such as neurons, can be cultured over the electrodes. Over time, as the cultures become established, they form cohesive networks and present an electrophysiological profile. The resulting electrical activity, spontaneous or induced firing of neurons, is captured from each electrode on a microsecond timescale providing both temporally and spatially precise data. What is optogenetics? Using light to control cells. Optogenetics is a technique that involves the use of light to control cell function. Cells are first genetically modified to express light-sensitive ion channels, called opsins. Then, light can be used to activate the opsin. The most well-known opsins are light-gated ion channels that can control the excitability of the cell membrane. When activated by the opsin-specific wavelength of light, the channels open allowing ions to flow across the cell membrane to either excite or inhibit the cell. Optogenetics enables precise control over a targeted cell population. [koTQG-LJ6gg] |
| Category | Science & Technology |
| Tags | iPSC | Stem Cells | Neural iPS cells | Neurons | Brain in a dish | Optogenetics | Channel rhodopsin | ChR2 | Neural network | Neural circuit | Neural activity | Functional assay | label free | real time | Assay | In Vitro | Screening | multiwell MEA system | MEA electrophysiology | Neural electrophysiology | MEA | Microelectrode Array | Multielectrode Array | Maestro Pro | Maestro Edge | Lumos | Axion BioSystems |
