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| Name | Webinar: Resolving flexibility and heterogeneity with 3D Variability Analysis |
| Video Uploader | Video From Structura Biotechnology Inc. |
| Upload Date | This Video Uploaded At 30-06-2020 18:29:53 |
| Video Discription | Learn how the new 3D Variability Analysis (3DVA) algorithm in cryoSPARC can reveal new functional and biological insight into the conformational and flexible motion dynamics of a protein molecule from single particle cryo-EM data. We will cover the new concepts introduced by the algorithm, interpretation of results, several case studies and examples, practical considerations to keep in mind when working on your own data, and live audience Q&A. 3DVA has already been used in many notable structural studies to shed light on protein dynamics, including GPCR structures and the SARS-CoV-2 spike protein. To read ahead, see the 3DVA preprint at https://www.biorxiv.org/content/10.1101/2020.04.08.032466v1 To learn more about cryoSPARC, please visit: https://cryosparc.com/ 00:00 Introduction 57:44 Q&A [0O781Od1z_E] |
| Category | Science & Technology |
| Tags | Structura | Biotechnology | Toronto | cryo-EM | SLAC | Cryo-EM | Cryo | EM | Electron Microscopy | SPA | Single Particle Analysis | Cryo-EM Image Analysis | cryoSPARC | Single Particle Reconstruction | Electron Microscope | 3D Variability Analysis | Non-Uniform Refinement | Homogeneous Refinement | Heterogeneous Refinement | Ab-initio | Motion Correction | CTF | CTF Estimation | Particle Picking | Blob Picking | Template Picking | 2D Classification | Aberration Correction | Beam Tilt | 3DVA | PPCA | PCA | Webinar | Variability |
